The ingredients in this formula are generally well tolerated in healthy adults at the doses included. Glycine, L-Theanine, lemon balm, and magnesium bisglycinate all have strong safety profiles at these levels. Saffron at 15mg is a moderate dose and is within the range used safely in human studies. The label advises that pregnant and breastfeeding women seek medical advice before use, and that the product is unsuitable for children. If you take prescribed medication, particularly for sleep, anxiety, or blood pressure, speak to your GP before use as some ingredients, particularly lemon balm and magnesium, can have additive effects with certain medications.