Berberine, the lead ingredient at 300mg per capsule, can cause mild digestive discomfort including nausea, loose stools, or stomach cramps in some people, particularly when first starting. Taking the capsule with food helps reduce this. Berberine can interact with medications including metformin, blood pressure medications, blood thinners, and immunosuppressants, so if you take any prescribed medication you must speak to your GP before use. Berberine is not recommended during pregnancy or breastfeeding. Saffron at high doses can also have effects on mood and uterine activity, so pregnant women should avoid this product. Do not exceed the stated dose.